A very good club area is Calle 12 from 1th Ave to the beach. There are a number of clubs in this area and plenty of nightlife (-; Also at the other end of 5th try Calle 4 on the beach onother popular club Captain Tutic's
I'm from Houston too.. and there is no danger that i know of? unless of course you go to the places where you would find yourself in danger, that is like going to 5th ward or 3rd ward in Houston. its ok to come down, I drove down here with my 10 y...